Established to decentralize road maintenance administration of the Department of Highways in Uttaradit Province for greater efficiency, the Department of Highways established the Uttaradit Road Maintenance Office No. 2 on October 1, 1992, according to Department of Highways Order No. J.1.9/13/2535 dated September 30, 1992. A temporary office was set up in the area of ​​Uttaradit Highway District 1, responsible for road sections and maintenance units transferred from Uttaradit Highway District 1, Phitsanulok Highway District, and Dan Sai Highway District.
Later, the Department of Highways issued Order No. J.1.9/8/2536 dated June 21, 1993, changing the location from the Uttaradit Maintenance Office No. 2 to the Uttaradit Highway District No. 2, and commencing operations at the Uttaradit Highway District No. 2 office.
This office is located at Km. 9+700 on Highway No. 1045, Uttaradit – Ruamchit section, on November 28, 1994. The original office site is now the location of the Uttaradit Highway Maintenance Section office, with an area of ​​approximately 49 rai.